Applications

Pathmaker Bio is developing a novel, patented class of molecules called Conversomes™. These Conversome™ molecules can identify and "reverse-translate" peptide sequences into DNA readouts, while also detecting post-translational modifications. During the assay, the process generates a stretch of oligonucleotide known as a pDNA™ sequence. This sequence serves as a surrogate readout for the target protein or peptide and can be analyzed on any standard DNA analysis platform. By converting protein information into DNA, this powerful chemistry enables rapid, highly quantitative protein detection. Additionally, Pathmaker Bio’s proprietary chemistry can be used to generate on-demand "synthetic antibodies" - custom affinity reagents tailored to target any specific protein or peptide sequence. The entire workflow is designed as a simple benchtop process that seamlessly integrates with widely accessible DNA analysis platforms, including qPCR and NGS.